The three major skin cancer types - squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and melanoma - account for >70% of all cancer. Although these cancers all derive from the outer skin layer (epidermis), variability in cell type composition and interactions causes substantial cross-cancer differences in disease initiation and invasive and metastatic potential. A knowledgebase of cell type composition and cell-to-cell interactions within the three skin cancers is needed to aid the assessment of risks and prognosis upon patient presentation. Here we integrated six distinct yet complementary spatial single-cell technologies to build the largest cell atlas and interactome of SCC, BCC, and melanoma to date. First, we performed single-cell RNA sequencing (scRNAseq) on >50,000 cells from 11 paired healthy and SCC patient biopsies. We found 30 molecularly-distinct cell types/states, 18 of which were significantly enriched in SCC tissues and expressed strong transcriptional signatures of pro-tumour signalling. GeoMx spatial proteomics data independently validated the presence of rare immune cell types defined by scRNAseq. Visium and CosMx transcriptomic analyses were performed for all three skin cancer types to map spatial neighbourhoods and construct a cell-to-cell interaction atlas. We screened all captured ligand-receptor (LR) pairs in 121 possible cell type combinations to reveal signalling between cancer types/states, patients, and tissue regions. With CosMx data, we found between 2-12 LR pairs specific to each cancer type, some of which have been previously implicated in skin cancer progression and metastasis. We independently validated two key LR interactions, PD1_PDL1 and IL34_CSF1R, using Opal Multiplex Polaris and RNAscope data. Downstream analysis of IL34_CSF1R signalling zones suggested enrichment of IL34-related antigen presenting pathways in melanoma. We also present a valuable resource available for users to explore interactively at the skInteractive web browser: https://skincspatialatlas.web.app/