Next-generation sequencing has enabled transcriptome profiling down at a single-cell resolution. Using this technology, spatial genomics/transcriptomics tools have been developed and implemented to answer various scientific questions. Since we (LifeStrands Genomics Singapore, LSG) function as a certified service provider for spatial genomics experiments, including NanoString’s GeoMx Digital Spatial Profiler, 10x Genomics' Visium, ACDBio's RNAscope and soon CosMx, we compared two technologies; GeoMx DSP and Visium on the same sample to reach a consensus, so that we can recommend scenarios to researchers for these tools' advantageous. We identified 17,428 genes in Visium and 18,676 genes in Whole Transcriptome Atlas in GeoMx DSP. We used full ROIs in GeoMx DSP and selected three square regions on the tissue to be placed on Visium slide. For ROI selection purposes, colorectal tissue was divided into 3 sections, edge facing the lumen, base of the villi and Peyer's patch. We identified similar gene signatures across the two technologies. However, the two technologies' major differences were significant regarding the hands-on time, requirement for machinery, and flexibility to select area. Furthermore, data specificity was also different between the two technologies. As a result, we recommend that both technologies provide spatial transcriptome data with certain advantages which comes to flexibility over ease.